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. 2023 Apr 16;28(8):3513. doi: 10.3390/molecules28083513

Table 4.

LSA-FAS-Cu2+ catalyzed three-component reactions of 4-aminoindoles, alkynes, and aldehydes [34] 1.

graphic file with name molecules-28-03513-i003.jpg
Entry R1 R2 Yield (%) 2
1 4-Me-Ph Et 86
2 Ph Et 61
3 4-Br-Ph Et 46
4 4-CF3-Ph Et 64
5 2-OMe-Ph Et 55
6 2-NaPh Et 60
7 2-Cl,3-Cl-Ph Et 42
8 (3-OMe,4-OMe,5-OMe)-Ph Et 37
9 graphic file with name molecules-28-03513-i004.jpg Et 64
10 CH2CH2-Ph Et 45
11 Me Et 80
12 Pr Et 74
13 CH2tBu Et 71
14 graphic file with name molecules-28-03513-i005.jpg Et 77
15 4-Me-Ph Me 65

1 Reaction conditions: 4-aminoindole/aldehyde/alkyne = 1.5:1:1.5, LSA-FAS-Cu2+ (20 mol%), EtOH (1 mL), 60 °C, 7 h. 2 Isolated yield.