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. 2023 Apr 16;28(8):3513. doi: 10.3390/molecules28083513

Table 6.

LSA-FAS-Cu2+-catalyzed synthesis of aminonaphthalene derivatives [34] 1.

graphic file with name molecules-28-03513-i012.jpg
Entry R1 R2 R3 Yield (%) 2
1 Ph H 4-Me-Ph 81
2 Ph H 4-OMe-Ph 85
3 Ph H 4-t-Bu-Ph 79
4 Ph H 4-Br-Ph 55
5 Ph H (3-OMe,4-OMe)-Ph 66
6 Ph H 1-naphthalene 70
7 Ph H Bn 61
8 Ph H n-Bu 83
9 Ph H graphic file with name molecules-28-03513-i013.jpg 88
10 Ph H graphic file with name molecules-28-03513-i014.jpg 81
11 Ph Cl 4-Me-Ph 78
12 Ph F 4-Me-Ph 63
13 4-F-Ph H 4-Me-Ph 71
14 n-hexyl H 4-Me-Ph 54
15 cyclohexenyl H 4-MePh 42
16 Ph H 4-NO2Ph n.d.
17 4-OMe-Ph H 4-Me-Ph n.d.

1 Reaction conditions: ketone (0.2 mmol), amine (0.24 mmol), LSA-FAS-Cu2+ (10 mol%), DCE (1 mL), 100 °C, 12 h. 2 Isolated yield.