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Bioreductive prodrugs. (a) Chemotypes used for bioreductive clinical prodrugs: (i) aliphatic N-oxides, (ii) aromatic N-oxides, and (iii) nitroimidazoles and nitroaromatics. (b) Bicyclic disulfides targeting the Trx/TrxR system, one of the new motifs for bioreductive prodrug development introduced in this paper.
