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. 2023 Mar 8;9(4):675–684. doi: 10.1021/acscentsci.2c01548

Figure 5.

Figure 5

DIP is a selective binding pocket for M17-B15. (A) Venn diagram of DEGs in treated groups of DHT, Enz, and M17-B15. (B) The relative mRNA expression of CDC20, CENPF and MKI67 in LNCaP cells determined by qPCR. (C) Phylogenetic tree of the LBDs of 48 human NRs. (D) Sequence identities of the AR LBP and DIP to other 47 NR LBDs. The antagonistic activities (top) and agonistic activities (bottom) of M17-B15 toward PR (E), GR (F), and MR (G). *P < 0.05, **P < 0.01 vs DHT group; ns, not significant.