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. 2023 Apr 14;14:1149874. doi: 10.3389/fimmu.2023.1149874

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Copyright © 2023 Kyuuma, Kaku, Mishima-Tsumagari, Ogawa, Endo, Tamura, Ishikura, Mima, Nakanishi and Fujii

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Front (Left) and bottom (Right) views of the predicted 3-dimensional structure of the ozoralizumab-TNFα trimer complex. The TNFα trimer molecule is shown with the molecular surface of each TNFα monomer unit colored dark yellow, light yellow, and light gray, respectively. The framework of the anti-TNFα NANOBODY^® and the framework of the anti-HSA NANOBODY^® are colored green and white, respectively. The CDRs are defined according to the Kabat numbering scheme and colored orange (CDR 1 and 2) and red (CDR3), respectively, and the two linkers are colored dark gray.