Table 3.
Univariable and multivariable Cox regression of the impact of nutritional status on all-cause mortality.
| NUTRITIONAL INDICES | Model 0 | Model 1 | Model 2 | ||||
|---|---|---|---|---|---|---|---|
| Unadjusted-HR (95% CI) | p-Values | Adjusted-HR (95% CI) | p-Values | Adjusted-HR (95% CI) | p-Values | ||
| GNRI | |||||||
| Absent risk | (GNRI > 98) | [Ref] | ·· | [Ref] | ·· | [Ref] | ·· |
| Mild risk | (92 < GNRI ≤ 98) | 1.56 (0.55–4.40) | 0.40 | 1.38 (0.47–4.07) | 0.56 | 1.06 (0.39–6.52) | 0.51 |
| Moderate risk | (82 < GNRI ≤ 92) | 4.45 (1.67–11.85) | 0.003 | 4.19 (1.44–12.21) | 0.009 | 5.62 (1.23–25.80) | 0.03 |
| Severe risk | (GNRI ≤ 82) | 6.33(2.37–16.88) | <0.001 | 4.43 (1.58–12.40) | 0.005 | 5.59 (1.30–23.96) | 0.02 |
| GNRI per 1-point decreased | 1.06 (1.03–1.09) | <0.001 | 1.05 (1.02–1.09) | 0.001 | 1.06 (1.01–1.10) | 0.01 | |
| PNI | |||||||
| Absent risk | (PNI > 38) | [Ref] | ·· | [Ref] | ·· | [Ref] | ·· |
| Moderate risk | (35 < PNI ≤ 38) | 3.80 (1.55–9.30) | 0.004 | 2.92 (1.17–7.30) | 0.02 | 3.80 (0.97–14.97) | 0.06 |
| Severe risk | (PNI ≤ 35) | 3.56 (1.65–7.66) | 0.001 | 2.65 (1.19–5.89) | 0.02 | 2.16 (0.70–6.64) | 0.18 |
| PNI per 1-point decreased | 1.09 (1.04–1.14) | <0.001 | 1.07 (1.03–1.12) | 0.002 | 1.08 (1.01–1.15) | 0.02 | |
| CONUT | |||||||
| Absent risk | (CONUT 0–1) | [Ref] | ·· | [Ref] | ·· | [Ref] | ·· |
| Mild risk | (CONUT 2–4) | 1.33 (0.55–3.24) | 0.53 | 1.40 (0.56–3.52) | 0.47 | 1.79 (0.57–5.62) | 0.32 |
| Moderate risk | (CONUT 5–8) | 4.12 (1.55–10.92) | 0.004 | 3.72 (1.33–10.37) | 0.01 | 3.33 (0.85–13.06) | 0.09 |
| Severe risk | (CONUT 9–12) | 6.11 (1.83–20.36) | 0.003 | 4.67 (1.33–16.37) | 0.02 | 3.25 (0.61–17.43) | 0.17 |
| COUNT per 1-point increased | 1.26 (1.12–1.40) | <0.001 | 1.22 (1.08–1.37) | 0.001 | 1.16 (0.99–1.36) | 0.06 | |
Model 0 (the unadjusted analysis) was a crude analysis without confounding adjustment. Model 1 (the main analysis) was adjusted for age (continuous), sex (female or male), tumor progression before RN (with or without), lower cranial nerves injury (with or without), bilateral necrosis (with or without), necrosis involving ≥2 brain regions (with or without), and history of stroke (with or without). Model 2 (the sensitivity analysis) was adjusted for Model 1, and the time interval from RT to RN diagnosis (continuous), RT techniques (IMRT or non-IMRT), prior TNM stage (stage I, II, III, or IV), having received chemotherapy (with or without), tumor RT dose (continuous) and neck RT dose (continuous). A total of 259 patients were included in Model 2 (139 patients were excluded due to missing data). Abbreviations: GNRI, Geriatric Nutritional Risk Index; PNI, Prognostic Nutritional Index; CONUT, Controlling Nutritional Status; HR, Hazard Ratio.