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. 2023 Apr 28;42:105. doi: 10.1186/s13046-023-02670-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — LINC00183 promotes T-LBL progression and chemoresistance in vivo and in vitro. A The differential expression of lncRNAs in 3 remission and relapse tissues (left), and in 3 chemosensitivity and chemoresistance tissues (right). B Kaplan-Meier curves of progression-free survival (PFS) and overall survival (OS) stratified by LINC00183 expression in T-LBL patients from the SYSUCC dataset. C Kaplan-Meier curves of PFS and OS stratified by LINC00183 expression in T-LBL patients from the AHAMU dataset. D MTT assays using T-LBL and LINC00183-overexpression T-LBL cells under the treatment of Dox (100ng/ml). E The protein expression of Bax, Bcl-2, caspase-3, and cleaved-caspase-3 in T-LBL and LINC00183-overexpression T-LBL cells treated with Dox (100ng/ml). F Flow cytometric analysis of T-LBL cells and LINC00183-overexpression T-LBL under the treatment of Dox (100ng/ml). G The tumor growth curve of mouse xenografts. The xenografts were formed SUP-T1 or SUP-T1-LINC00183 cells treated with Dox (1 mg/kg/time, 3 times/week). H The tumor size of mouse xenografts. I The protein expression of Bax, Bcl-2, and cleaved-caspase-3 in xenograft tissues. 3 xenografts tissues for each group. Dox, doxorubicin. LINC00183, ectopic LINC00183 expression in T-LBL cells. SUP-T1-LINC00183, SUP-T1 cells transfected with LINC00183. *, P < 0.05