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. 2023 Apr 28;42:105. doi: 10.1186/s13046-023-02670-9

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — miR-371b-5p suppresses T-LBL progression and chemoresistance in vivo and in vitro. A Kaplan-Meier curves of progression-free survival (RFS) and OS stratified by miR-371b-5p expression in patients from the SYSUCC and AHAMU datasets. B MTT assay using T-LBL cells transfected by LINC00183, LINC00183 + miR-371b-5p, shLINC00183, shLINC00183 + anti-miR-371b-5p treated with Dox (100ng/ml). C The protein levels of Bax, Bcl-2 in SUP-T1 cells transfected by LINC00183, and LINC00183 + miR-371b-5p treated with Dox (100ng/ml). D Flow cytometric analysis of T-LBL cells transfected by LINC00183, shLINC00183, LINC00183 + miR-371b-5p, and shLINC00183 + anti-miR-371b-5p treated with Dox (100ng/ml). E The tumor growth curve of mouse xenografts. The xenografts were formed SUP-T1-LINC00183 or SUP-T1-LINC00183 + miR-371b-5p cells treated with Dox (1 mg/kg/time, 3 times/week). F The tumor size of mouse xenografts. G The protein expression of Bax, Bcl-2, and cleaved-caspase-3 in xenograft tissues. 3 xenografts tissues for each group. LINC00183, ectopic LINC00183 expression in T-LBL cells. shLINC00183, T-LBL cells were transfected by shRNA targeting LINC00183. LINC00183 + miR-371b-5p, T-LBL cells were transfected with LINC00183 and miR-371b-5p. shLINC00183 + anti-miR-371b-5p, T-LBL cells were transfected with shLINC00183 and anti-miR-371b-5p. Dox, doxorubicin. *, P < 0.05