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(a) FTIR spectra of Dox in Chit5-MUA-20 micelles at 22–45 °C. (b) Corresponding dependences of I1631, ratio I1080/I1115 (the peaks of chitosan C–O–C bonds, which characterize the ratio of the hydrophilic to hydrophobic component of chitosan), and 1630–1640 cm−1 peak position (the C=O bond, which characterizes the microenvironment of the carbonyl group of doxorubicin, which becomes more hydrophilic) on temperature. I—intensity.
