Table 2.
Population PK parameter estimates in the final model and bootstrap
| Final model | Bootstrap method | ||||
|---|---|---|---|---|---|
| Parameters (Unite) |
Estimate | Standard Error (%SE) |
Parameters (Unite) |
Estimate | Standard Error (%SE) |
| Fixed effect | Fixed effect | ||||
| CL (L/h) | 1.56 | 4.50 | CL (L/h) | 1.56 | 4.47 |
| CLd (L/h) | 2.41 | 11.8 | CLd (L/h) | 2.41 | 11.6 |
| Vc (L) | 12.5 | 5.67 | Vc (L) | 12.5 | 5.65 |
| Vp (L) | 29.9 | 17.3 | Vp (L) | 29.9 | 16.7 |
| Random effect (%) | Random effect (%) | ||||
| ωCL*Vc | 100 | 12.7 | ωCL*Vc | 100 | 12.5 |
| ωCL | 39.4 | 6.4 | ωCL | 39.4 | 6.16 |
| ωVc | 28.6 | 15.5 | ωVc | 28.6 | 15.3 |
| Residual error (%) | Residual error (%) | ||||
| Proportional residual (%) | 27.86 | 9.11 | Proportional residual (%) | 27.86 | 9.09 |
CL The clearance in central compartment, CLd The clearance between central compartment and peripheral compartment, Vc The volume distribution in central compartment, Vp The volume in peripheral compartment, ωCL*Vc The correlation of CL and Vc