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. 2023 Apr 28;23:174. doi: 10.1186/s12883-023-03203-9

Table 2.

Previously used preventive medication before starting a monoclonal antibody including the reason for discontinuing the treatment

Non-Responder Side Effects Loss-of-Efficacy Other Total
Beta-Blocker 48 (57.1) 18 (21.4) 7 (8.3) 11 (13.1) 84 (49.1)
Topiramate 35 (41.7) 36 (42.9) 5 (6.0) 8 (9.5) 84 (49.1)
Flunarizine 29 (46.8) 21 (33.9) 3 (4.8) 9 (14.5) 62 (36.3)
Amitriptyline 38 (59.4) 15 (23.4) 1 (1.6) 10 (15.6) 64 (37.4)
OnabotulinumtoxinA 17 (85.0) 1 (5.0) - 2 (10.0) 20 (11.7)
Valproic acid 10 (55.6) 5 (27.8) 2 (11.1) 1 (5.6) 18 (10.5)
Candesartan 5 (62.5) - - 3 (37.5) 8 (4.7)
Venlafaxine 4 (57.1) 0 (0.0) - 3 (42.9) 7 (4.1)
Tanacetum parthenium 6 (85.7) - - 1 (14.3) 7 (4.1)
Other 23 (65.7) 4 (11.4) - 8 (22.9) 35 (20.5)

Values are absolute numbers and percent (%)