Table 2.

Predicted RBD–ACE2 interaction energy. Values of interaction energy are expressed in Kcal/mol.

	BA.2	XBB	XBB.1	XBB.1.5
Foldx 5.0	−6.19 ± 0.32	−3.54 ± 0.30	−3.54 ± 0.30	−4.57 ± 0.27
PRODIGY	−11.70 ± 0.05	−11.48 ± 0.05	−11.48 ± 0.05	−10.84 ± 0.05
MM/GBSA	−68.43 ± 2.10	−60.82 ± 0.99	−60.82 ± 0.99	−62.44 ± 2.28