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. 2023 Apr 15;15(4):974. doi: 10.3390/v15040974

Figure 6.

Figure 6

When JEV enters the release phase of the life cycle, JEV can promote BAK activation to activate the MOMP process. Subsequently, the release of ROS promotes the combination of pro-caspase-1, ASC, and pro-NLRP3 to form the NLRP3 inflammasome, forming an activated form of caspase-1. Then, caspase-1 activates inflammatory factors such as IL-1β and cleaves the N-segment of the GSDMD protein. Finally, the GSDMD-N protein aggregates on the cell membrane to form pores, releasing IL-1β and virions.