Table 2.
Echocardiographic data before and after 6 months of sacubitril/valsartan therapy.
| Characteristics | Time 0 | 6 Months | p-Value |
|---|---|---|---|
| LV end-diastolic diameter (mm) | 71.3 ± 8.4 | 66.9 ± 7.6 | 0.001 |
| LV end-systolic diameter (mm) | 57.8 ± 9.4 | 53.1 ± 9.3 | 0.002 |
| Interventricular septum (mm) | 9.6 ± 1.7 | 9.9 ± 1.9 | 0.280 |
| LV ejection fraction (%) | 29.3 ± 6.4 | 35.2 ± 8.6 | 0.001 |
| Mean septal/lateral E/e’ | 13.6 ± 4.5 | 12.8 ± 4.6 | 0.449 |
| Pulmonary artery systolic pressure (mmHg) | 38.3 ± 12.2 | 30.9 ± 10.6 | <0.001 |
| Left atrium volume (mL/m2) | 51.5 ± 22.6 | 43.7 ± 15.8 | 0.004 |
| Right atrium volume (mL/m2) | 33.1 ± 4.4 | 28.5 ± 13.5 | 0.036 |
| Tricuspid annular systolic excursion (mm) | 19.2 ± 4.4 | 20.0 ± 4.8 | 0.404 |
| Left atrial strain parameters | |||
| LA strain reservoir (%) | 11.5 ± 6.2 | 16.1 ± 7.8 | <0.001 |
| LA strain conduit (%) | −6.3 [−8.5–−4.4] | −7.4 [−11.4–−5.0] | 0.003 |
| LA strain contraction (%) * | −7.2 ± 4.1 | −10.9 ± 3.9 | 0.003 |
| LA strain rate reservoir (s−1) | 0.49 ± 0.22 | 0.65 ± 0.22 | <0.001 |
| LA strain rate conduit (s−1) | −0.47 [−0.68–−0.29] | −0.58 [−0.87–−0.39] | 0.018 |
| LA strain rate contraction (s−1) * | −0.82 [−1.14–−0.47] | −1.08 [−1.48–−0.94] | 0.018 |
| Left ventricular strain parameters | |||
| Global longitudinal strain (%) | −7.0 ± 2.6 | −8.9 ± 2.8 | 0.001 |
| Peak longitudinal strain (%) | −5.6 ± 2.0 | −9.3 ± 2.7 | <0.001 |
| Longitudinal systolic strain rate (s−1) | −0.32 ± 0.11 | −0.47 ± 0.14 | <0.001 |
| Longitudinal early diastolic strain rate (s−1) | 0.25 [0.18–0.41] | 0.46 [0.27–0.62] | <0.001 |
| Longitudinal late diastolic strain rate (s−1) * | 0.31 ± 0.17 | 0.44 ± 0.19 | 0.002 |
| Peak radial strain (%) | 5.9 [4.3–9.2] | 11.7 [7.7–14.7] | <0.001 |
| Radial systolic strain rate (s−1) | 0.66 ± 0.26 | 0.90 ± 0.30 | 0.001 |
| Radial early diastolic strain rate (s−1) | −0.54 ± 0.48 | −0.95 ± 0.72 | 0.001 |
| Radial late diastolic strain rate (s−1) * | −0.58 [−0.86–−0.37] | −0.71 [−1.20–−0.51] | 0.061 |
| Peak circumferential strain (%) | −7.7 ± 2.3 | −9.9 ± 2.5 | 0.001 |
| Circumferential systolic strain rate (s−1) | −0.78 [−0.97–−0.58] | −0.87 [−1.10–−0.73] | 0.026 |
| Circumferential early diastolic strain rate (s−1) | 0.87 ± 0.24 | 0.95 ± 0.21 | 0.102 |
| Circumferential late diastolic strain rate (s−1) * | 0.48 [0.34–0.78] | 0.59 [0.50–0.82] | 0.041 |
* Left atrial contraction phase strain, contraction strain rate and left ventricular late diastolic strain rates were assessed exclusively in patients in sinus rhythm during the echocardiogram (n = 26, 74.3%). LV, Left ventricle; LA, Left atrium, Values are mean ± SD or median [Q1–Q3].