Table 3.
Echocardiographic parameters before and after 6 months of sacubitril/valsartan therapy according to sinus rhythm versus atrial fibrillation.
| Sinus Rhythm (n = 21) | Atrial Fibrillation (n = 14) | ||||||
|---|---|---|---|---|---|---|---|
| Left Atrial Parameters | Time 0 | 6 Months | p-Value | Time 0 | 6 Months | p-Value |
p-Value (Interaction) |
| LA volume (mL/m2) | 43.8 ± 13.2 | 38.6 ± 13.4 | 0.041 | 67.6 ± 29.6 | 54.4 ± 15.3 | 0.051 | 0.147 |
| Reservoir strain (%) | 13.9 ± 5.9 | 19.8 ± 6.5 | <0.001 | 7.0 ± 3.6 | 9.0 ± 4.5 | 0.080 | 0.027 |
| Conduit strain (%) | −6.0 [−8.3–−4.4] | −7.3 [−10.8–−4.8] | 0.024 | −6.3 [−10.8–−3.9] | −7.4 [−14.4–−5.3] | 0.056 | 0.850 |
| Reservoir strain rate (s−1) | 0.54 ± 0.20 | 0.74 ± 0.15 | 0.001 | 0.38 ± 0.23 | 0.46 ± 0.24 | 0.135 | 0.111 |
| Conduit strain rate (s−1) | −0.49 [−0.74–−0.37] | −0.59 [−0.90–−0.41] | 0.060 | −0.34 [−0.60–−0.27] | −0.42 [−0.72–−0.34] | 0.090 | 0.769 |
| Left ventricular strain parameters | |||||||
| LV end-diastolic diameter (mm) | 70.8 ± 8.8 | 66.4 ± 7.4 | 0.006 | 72.6 ± 7.6 | 68.0 ± 8.4 | 0.052 | 0.975 |
| LV ejection fraction (%) | 29.6 ± 6.4 | 40.1 ± 7.9 | <0.001 | 28.7 ± 6.5 | 33.9 ± 8.8 | 0.070 | 0.032 |
| Global longitudinal strain (%) | −7.4 ± 2.5 | −9.7 ± 2.5 | 0.001 | −5.9 ± 2.7 | −7.1 ± 2.7 | 0.227 | 0.299 |
| Peak longitudinal strain (%) | −6.1 ± 2.0 | −10.0 ± 2.6 | <0.001 | −4.5 ± 1.7 | −7.8 ± 2.3 | <0.001 | 0.477 |
| Longitudinal systolic strain rate (s−1) | −0.32 ± 0.11 | −0.50 ± 0.12 | <0.001 | −0.34 ± 0.12 | −0.42 ± 0.17 | 0.095 | 0.046 |
| Longitudinal early diastolic strain rate (s−1) | 0.24 [0.17–0.41] | 0.50 [0.27–0.65] | 0.001 | 0.27 [0.20–0.41] | 0.44 [0.25–0.52] | 0.014 | 0.078 |
| Peak radial strain (%) | 5.9 [4.9–9.4] | 11.3 [7.6–14.3] | 0.001 | 5.2 [4.0–9.2] | 12.9 [8.8–14.9] | 0.005 | 0.618 |
| Radial systolic strain rate (s−1) | 0.68 ± 0.25 | 0.95 ± 0.30 | 0.002 | 0.63 ± 0.31 | 0.78 ± 0.19 | 0.227 | 0.357 |
| Radial early diastolic strain rate (s−1) | −0.66 ± 0.31 | −1.10 ± 0.62 | 0.005 | −0.26 ± 0.67 | −0.61 ± 0.85 | 0.117 | 0.739 |
| Peak circumferential strain (%) | −7.5 ± 2.3 | −10.7 ± 2.4 | <0.001 | −8.0 ± 2.4 | −8.2 ± 1.7 | 0.855 | 0.028 |
| Circumferential systolic strain rate (s−1) | −0.79 [−1.10–−0.62] | −0.98 [−1.25–−0.77] | 0.009 | −0.64 [−0.85–−0.50] | −0.67 [−0.74–−0.64] | 0.919 | 0.129 |
| Circumferential early diastolic strain rate (s−1) | 0.84 ± 0.26 | 0.98 ± 0.23 | 0.025 | 0.90 ± 0.15 | 0.94 ± 0.17 | 0.563 | 0.065 |
LA, Left atrium; Values are mean ± SD or median [Q1–Q3].