Table 4.
Echocardiographic parameters before and after 6 months of sacubitril/valsartan therapy according to nonischemic etiology versus ischemic etiology.
| Nonischemic Etiology (n = 20) | Ischemic Etiology (n = 15) | ||||||
|---|---|---|---|---|---|---|---|
| Left Atrial Parameters | Time 0 | 6 Months | p-Value | Time 0 | 6 Months | p-Value |
p-Value (Interaction) |
| LA volume (mL/m2) | 56.2 ± 26.9 | 44.5 ± 15.8 | 0.005 | 44.9 ± 12.6 | 42.6 ± 16.2 | 0.442 | 0.053 |
| Reservoir strain (%) | 10.1 ± 4.8 | 15.0 ± 7.8 | 0.001 | 13.5 ± 7.4 | 17.7 ± 7.9 | 0.011 | 0.726 |
| Conduit strain (%) | −5.5 [−9.5–−4.2] | −6.0 [−12.5–−4.2] | 0.059 | −6.4 [−8.5–−4.4] | −7.8 [−10.9–−6.9] | 0.033 | 0.957 |
| Contraction strain (%) | −6.2 ± 4.4 | −10.6 ± 4.8 | <0.001 | −8.2 ± 3.6 | −11.1 ± 2.7 | 0.052 | 0.327 |
| Reservoir strain rate (s−1) | 0.47 ± 0.21 | 0.65 ± 0.24 | 0.001 | 0.51 ± 0.24 | 0.64 ± 0.20 | 0.065 | 0.509 |
| Conduit strain rate (s−1) | −0.52 [−0.79–−0.28] | −0.63 [−0.90–−0.35] | 0.184 | −0.46 [−0.63–−0.29] | −0.55 [−0.70–−0.41] | 0.023 | 0.966 |
| Contraction strain rate (s−1) | −0.58 [−1.10–0.33] | −1.22 [−1.51–−0.71] | 0.016 | −0.89 [−1.25–−0.66] | −1.07 [−1.28–−1.03] | 0.285 | 0.096 |
| Left ventricular strain parameters | |||||||
| LV end-diastolic diameter (mm) | 72.4 ± 7.9 | 66.6 ± 8.3 | <0.001 | 70.0 ± 9.0 | 67.5 ± 6.9 | 0.225 | 0.167 |
| LV ejection fraction (%) | 28.1 ± 7.1 | 38.9 ± 10.2 | <0.001 | 31.0 ± 5.0 | 37.2 ± 6.0 | 0.002 | 0.083 |
| Global longitudinal strain (%) | −6.3 ± 2.1 | −8.9 ± 3.3 | 0.003 | −7.9 ± 3.0 | −9.0 ± 2.1 | 0.092 | 0.146 |
| Peak longitudinal strain (%) | −5.1 ± 1.6 | −9.7 ± 3.1 | <0.001 | −6.2 ± 2.4 | −8.8 ± 2.1 | <0.001 | 0.007 |
| Longitudinal systolic strain rate (s−1) | −0.31 ± 0.09 | −0.50 ± 0.16 | <0.001 | −0.34 ± 0.14 | −0.44 ± 0.12 | 0.003 | 0.054 |
| Longitudinal early diastolic strain rate (s−1) | 0.24 [0.17–0.39] | 0.48 [0.29–0.62] | 0.001 | 0.32 [0.18–0.42] | 0.46 [0.27–0.65] | 0.029 | 0.248 |
| Longitudinal late diastolic strain rate (s−1) | −0.28 ± 0.16 | −0.45 ± 0.23 | 0.031 | 0.34 ± 0.18 | 0.43 ± 0.16 | 0.029 | 0.371 |
| Peak radial strain (%) | 6.0 [4.3–9.8] | 10.4 [6.7–15.6] | 0.010 | 5.7 [4.8–7.9] | 12.2 [10.0–13.9] | 0.001 | 0.076 |
| Radial systolic strain rate (s−1) | 0.63 ± 0.23 | 0.95 ± 0.32 | 0.001 | 0.71 ± 0.31 | 0.83 ± 0.26 | 0.274 | 0.154 |
| Radial early diastolic strain rate (s−1) | −0.44 ± 0.42 | −0.90 ± 0.91 | 0.014 | −0.67 ± 0.53 | −1.03 ± 0.36 | 0.031 | 0.679 |
| Radial late diastolic strain rate (s−1) | −0.50 [−0.97–−0.34] | −0.67 [−1.29–−0.51] | 0.347 | −0.66 [−0.84–−0.41] | −0.74 [−1.16–−0.45] | 0.090 | 0.601 |
| Peak circumferential strain (%) | −7.4 ± 2.5 | −9.5 ± 2.7 | 0.036 | −8.0 ± 2.0 | −10.5 ± 2.2 | 0.008 | 0.779 |
| Circumferential systolic strain rate (s−1) | −0.64 [−0.92–−0.51] | −0.87 [−1.08–−0.74] | 0.021 | −0.85 [−1.12–−0.71] | −0.87 [−1.13–−0.69] | 0.530 | 0.135 |
| Circumferential early diastolic strain rate (s−1) | 0.88 ± 0.23 | 0.93 ± 0.22 | 0.396 | 0.87 ± 0.26 | 0.98 ± 0.21 | 0.081 | 0.598 |
| Circumferential late diastolic strain rate (s−1) | 0.45 [0.28–0.83] | 0.65 [0.50–0.99] | 0.170 | 0.51 [0.38–0.63] | 0.58 [0.45–0.79] | 0.099 | 0.609 |
LA, Left atrium; Values are mean ± SD or median [Q1–Q3].