Table 2.

Various reported flavonoid–flavonoid combinations against various cancer cells as well as in vivo models.

S. No	Flavonoid	Flavonoid	Cancer Type	Findings	Model	Cell Type	Reference
1	Quercetin, Naringenin	Kaempferol	Liver; prostate	Exhibited synergistic chemotherapeutic potential against two different cells.	In vitro	LNCaP; Hepa 1c1c-7	[85]
2	Quercetin	Kaempferol	Gut; breast	Exhibited synergistic effect against HuTu-80 and Caco-2.	In vitro	HuTu-80; Caco-2	[84]
3	Ellagic acid	Quercetin	Leukemia	Exhibited apoptosis and reduction of cell growth in human leukemia cells (MOLT-4).	In vitro	MOLT-4	[86]
4	Resveratrol	Quercetin	Colon	Enhanced chemotherapeutic potential was observed.	In vitro	HT-29	[90]
5	Resveratrol	Quercetin	Glioma	Induced senescence-like growth arrest in C6 rat glioma cells.	In vitro	C6	[121]
6	Quercetin	Catechin	Breast	Inhibited mammary tumor growth and metastasis in nude mice.	In vivo	MDA-MB-231	[122]
7	Kaempferol	Resveratrol	Prostate	Inhibited TNF-α and cytokine IL-10.	In vitro	RAW-264.7	[123]
8	Naringenin	Quercetin	Breast	Showed anticancer potential against MCF-7 breast cancer cells.	In vitro	MCF-7	[124]
9	Quercetin	ECGC	Prostate	Enhanced antiproliferative activity in androgen-independent PC-3 cells and in androgen-dependent LNCaP prostate cancer cells.	In vitro	PC-3; LNCaP	[125]
10	Quercetin	Catechin	Breast	Inhibited the primary tumor growth of breast cancer xenografts in a nude mouse model.	In vivo; in vitro	MDA-MB-231	[83]
11	Quercetin	Naringenin	Liver	Exhibited significant potential in reduction of carcinogenesis.	In vivo	-	[126]