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. 2023 Apr 12;13(4):549. doi: 10.3390/metabo13040549

Figure 1.

Figure 1

(A) Schematic of study design. Oral administration of NH4Cl, using stepwise dosing increase, induces murine acidosis. Urine pH was measured at baseline (D-7), D0, D3, D6, D9, D12, and D14. Blood gas was measured at baseline (D-7) and D14 for both control (n = 4) and acidosis (n = 4) groups. (B) Blood gas measurement. B1, pH, HCO3−, BE, Be(b) and AGapK levels in the blood; B2, pCO2, pO2, cTCO2, cSO2, cHgb, Hct level in blood; B3, Glu, lac and BUN level in blood. (C) urine pH, (D) body weight. Two tailed student’s t-test was used to determine differences between acidosis and control. * < 0.05; ** < 0.01, n.s. (non-significant). Actual bicarbonate (cHCO3−; mmol/L), base excess of extracellular fluid (BE(ecf); mmol/L), base excess of blood (BE(b); mmol/L), Anion gap (AGapK, mmol/L), Carbon dioxide partial pressure (pCO2; mmHg), oxygen partial pressure (pO2; mmHg), total carbon dioxide (cTCO2; mmol/L), oxygen saturation (cSO2; %), hematocrit (Hct; %PCV), hemoglobin (cHgb; %), Glucose (Glu; mg/dL), lactate (Lac; mmol/L), Blood urea nitrogen (BUN; mmol/L).