Table 1.
Studies investigating the impact of radiotherapy technique and modality on osteoradionecrosis of the jaws rates.
| Reference | Study Year | Patients (N) |
Tumor Primary | Treatment Technique/Modality | ORNJ Prevalence |
|---|---|---|---|---|---|
| Maesschalck et al. [69] | 2016 | 234 | HNC | IMRT vs. 3D-CRT | 10% vs. 11% |
| Nguyen et al. [10] | 2012 | 83 | OPC | IMRT or IGRT | 1.2% |
| Moon et al. [70] | 2017 | 252 | OCC or OPC | IMRT vs. 3D-CRT | 5.5% |
| Aarup-Kristensen et al. [8] | 2019 | 1224 | HNC | IMRT | 4.6% |
| Yilmaz et al. [68] | 2023 | 263 | NPC | IMRT | 8.7% |
| Balermpas et al. [71] | 2022 | 875 | HNC | IMRT | 5.0% (all cases with tooth extraction pre-IMRT) |
| Zhang et al. [72] | 2017 | 584 | OPC | IMPT vs. IMRT | 2.0% vs. 7.7% |
| Singh et al. [15] | 2022 | 122 | OPC | IMPT | 10.6% |
| Musha et al. [73] | 2021 | 11 | HNC | Carbon ion therapy | 45.5% |
Abbreviations: ORNJ: Osteoradionecrosis of the jaw; IMRT: Intensity-modulated radiotherapy; 3D-CRT: Three-dimensional conformal radiotherapy; HNC: Head and neck cancer; OPC: Oropharyngeal cancer; OCC: Oral cavity cancer; NPC; Nasopharyngeal cancer; IMPT: Intensity-modulated proton therapy; NA: Not available.