Figure 4.

The DV2 peptide induces protection against ZIKV infection in AG129 mice. DV2 (12 µM) was incubated with 100 PFU ZIKV^BR for 30 min at 37 °C. The virus-peptide mixtures were s.c. inoculated in AG129 mice. The (a–d) morbidity, (e) clinical score, (f) weight changes, (g) viremia, and (h) survival were monitored in the infected animals for up to 17 days. The data are presented as means ±SD of the respective parameters in the different mice groups. Statistical significance was evaluated using two-way ANOVA followed by Bonferroni correction. Mantel-Cox test was used to analyze the survival results (*** p < 0.001; **** p < 0.0001; NS, not significant).