Table 3.

Functional annotation of the potential vaccine candidates identified in S. Pullorum R51.

Candidates	Annotation
dcrB	DcrB is up-regulated by conditions that promote the production of known virulence factors [55]
qseG	QseG is an OM protein necessary for translocation of TTSS effectors [56,57]
ompC	OmpC is the main protein responsible for the antibody-mediated memory bactericidal response induced by porins [58,59]
pagN	Haemagglutinin that facilitates the adhesion to and invasion of epithelial mammalian cells [33,60]
msrP	MSR system is involved in the repair of periplasmic proteins oxidized by hypochlorous acid HOCl, which is generated in particular within phagocytic cells [61,62]
sinH	sinH encodes an autotransporter protein that facilitates adhesion and invasion into host cells [63,64]
acrA	AcrA protein is a component of multidrug efflux pumps, which can increase drug resistance [65,66]
lpfA	Long polar fimbria protein A precursor [67,68]
peg.1230	Putative fimbriae stiH
peg.1041	Fimbrial operons sthB
peg.3954	Minor fimbrial subunit StfF
hslJ	Heat shock protein, correlated to E. coli resistance to the antibiotic Nov [69]
sodC	Periplasmic superoxide dismutase plays a critical role in this survival by combating phagocytic superoxide [70,71]
yhcN	YhcN is involved in the response to hydrogen peroxide stress [72]
nlpD	A virulence factor that permits S. Typhimurium to survive under acid stress conditions [73,74]
pstS	Phosphate ABC transporter, periplasmic phosphate-binding protein PstS [75,76]
peg.695	Involved in the transport of maltose and maltodextrins
chiP	Involved in the uptake of chitosugars [77]
peg.2134	N-acetylneuraminic acid outer membrane channel protein NanC
Fdh-2	Formate dehydrogenase
Peg.1210	Probable secreted protein
lpfB	Chaperone protein lpfB precursor [68]