FIG. 2.

Protection of V. anguillarum-infected salmon by CEME delivered via osmotic pump. CEME was constantly administered at the level of 80 μg/day (A) and 200 μg/day (B) into coho salmon though the use of implanted miniosmotic pumps with a pumping rate of 0.136 μl/h (CEME pump). The control groups (control) were injected with bacteria alone. The pump control groups (pump control) were implanted with osmotic pumps containing saline only. The temperature of the tank water was controlled to maintain the constant pumping rate. Twelve days after pump implantation, each fish was challenged with approximately 10,000 CFU of V. anguillarum.