Table 2.
Association between MMP2 rs243866 (−1575 G/A) SNP and LOAD in the whole population.
| Allele/ Genotype |
LOAD (n = 215) |
Controls (n = 373) |
Genetic Model | Logistic Regression Analysis | |
|---|---|---|---|---|---|
| p-Value | OR (95% CI) | ||||
| Allele contrast (A vs. G) | 0.53 | 1.09 (0.83–1.43) | |||
| G | 315 (73.26%) | 559 (74.93%) | Codominant (GA vs. GG) | 0.61 | 0.90 (0.61–1.33) |
| A | 115 (26.74%) | 187 (25.07%) | Codominant (AA vs. GG) | 0.20 | 1.52 (0.79–2.90) |
| GG | 123 (57.21%) | 212 (56.84%) | Dominant (AA + GA vs. GG) | 0.99 | 1.00 (0.70–1.44) |
| GA | 69 (32.09%) | 135 (36.19%) | Recessive (AA vs. GA + GG) | 0.16 | 1.57 (0.84–2.96) |
| AA | 23 (10.70%) | 26 (6.97%) | Over-dominant (GA vs. GG + AA) | 0.42 | 0.86 (0.59–1.25) |
| Log-additive | 0.54 | 1.09 (0.83–1.44) | |||
p-values, odds ratio (OR), and 95% confidence intervals (CI) for genotype comparisons were adjusted for APOE ε4 carrier status, age, and sex. LOAD: late-onset Alzheimer’s disease.