Table 3.
Association between MMP2 rs2285053 (−735 C/T) SNP and LOAD in the whole population.
| Allele/ Genotype |
LOAD (n = 215) |
Controls (n = 373) |
Genetic Model | Logistic Regression Analysis | |
|---|---|---|---|---|---|
| p-Value | OR (95% CI) | ||||
| Allele contrast (T vs. C) | 0.35 | 1.18 (0.83–1.66) | |||
| C | 367 (85.35%) | 651 (87.27%) | Codominant (CT vs. CC) | 0.30 | 1.24 (0.83–1.87) |
| T | 63 (14.65%) | 95 (12.73%) | Codominant (TT vs. CC) | 0.26 | 0.29 (0.03–2.90) |
| CC | 153 (71.16%) | 282 (75.60%) | Dominant (TT + CT vs. CC) | 0.40 | 1.19 (0.79–1.78) |
| CT | 61 (28.37%) | 87 (23.32%) | Recessive (TT vs. CT + CC) | 0.23 | 0.28 (0.03–2.75) |
| TT | 1 (0.47%) | 4 (1.07%) | Over-dominant (CT vs. CC + TT) | 0.27 | 1.26 (0.84–1.89) |
| Log-additive | 0.57 | 1.12 (0.76–1.63) | |||
p-values, odds ratio (OR), and 95% confidence intervals (CI) for genotype comparisons were ad-justed for APOE ε4 carrier status, age, and sex. LOAD: late-onset Alzheimer’s disease.