Table 5.
Statistical interaction between MMP2 rs243866 A and APOE ε4 alleles.
| MMP2 rs243866 A | APOE ε4 | LOAD (n = 215) |
Controls (n = 373) |
Logistic Regression Analysis | SF (p-Value) | |
|---|---|---|---|---|---|---|
| p-Value | OR (95% CI) | |||||
| − | − | 68 (31.63%) | 171 (45.84%) | reference | 0.76 (0.48) | |
| + | − | 56 (26.05%) | 133 (35.65%) | 0.83 | 1.06 (0.69–1.62) | |
| − | + | 55 (25.58%) | 41 (10.99%) | <0.0001 | 4.56 (2.67–7.79) | |
| + | + | 36 (16.74%) | 28 (7.51%) | <0.0001 | 3.68 (2.04–6.63) | |
The “−” sign means no copies of the allele, while the “+” sign denotes the presence of at least one copy of the allele. p-values, odds ratios (OR), and 95% confidence intervals (CI) were adjusted for age and sex. Synergy factor (SF) was computed as the ratio of the observed OR for both factors combined (3.68) to the predicted OR, assuming independent effects of each factor (1.06 × 4.56 = 4.83). Significant p-values are shown in bold. LOAD: late-onset Alzheimer’s disease.