Table 7.

Summary of the mechanism of action revised of PDT in WH.

Effect	Mediator	Phase of Wound Healing
Activation/suppression of the immune system	TNF-alfa IL1, IL6, IL10	Inflammation
Antibacterial activity	ROS	Chronic inflammation
Reepithelization, matrix formation	MMPs	Regeneration and remodeling
Neovascularization	VEGF	Regeneration and remodeling

TNF: tumoral necrosis factor; IL: interleukins; ROS: radical oxygen singlet; MMPs: metalloproteinases; VEGF: vascular endothelial growth factor.