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Time-kill kinetics of propranolol–azole combinations. (a) Propranolol (Pro) and fluconazole (Flu); (b) propranolol and voriconazole (Vor) and (c) propranolol and itraconazole (Itz). Note substantial lethality observed at sub-lethal concentrations of Pro–Itz combinations. The concentrations of propranolol, itraconazole and voriconazole are expressed in terms of their MIC values.
