Table 2.
Diversity of biomedical applications of polyhydroxyalkanoates and their derivatives in drug carriers and delivery.
| Bioproducts | Biopolymer Producers | Biomedical Applications | References |
|---|---|---|---|
| PHB | B. cereus VIT- SSR1 | PHA-chitosan with curcumin enabled cell viability of up to 98% in mouse fibroblasts | [119] |
| Commercial | Porous 3D implants enhanced the rate of regeneration of cranial defects in rats. Suitable for reconstructive osteogenesis | [56] | |
| PHA | B. cereus SPV | PHA loaded with Docetaxel killed cancerous cells (U-87MG) | [125] |
| P(3HB-3HV) | B. cereus FA11 | PHA-PEG with Epirubicin inhibited pathogens: Escherichia coli ATCC 11775, Pseudomonas aeruginosa ATCC 27853, and Staphylococcus aureus | [120] |
| C. necator H16 | PHA-PVA with derivatives of porphine used for photodynamic treatment of cancerous cells (Killed 94% of colon cancer cells) | [98] | |
| P(3HB-3HV) (6.5 mol% HV) | Hydrogen-oxidizing organisms | PHA-Doxorubicin killed HeLa cells | [118] |
| P(3HB-3HV) (12 mol% HV) | B. cereus FA11 | PHA-PVA loaded with Ellipticine inhibited 65% of cancerous cells | [123] |
| P(3HB-3HV) (16 mol% HV) | A. oremlandii OhiLAs | PHA-polyaniline with curcumin caused the arrest of the cell cycle at G0/G1 phase leading to death | [59] |
| P(3HB-3HO) (10 mol% HO) | Sinorhizobium fredii | PHA-PEG-Folic acid with Doxorubicin kills 3-fold higher HeLa cells | [97] |