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. 2023 Mar 28;132(9):1110–1126. doi: 10.1161/CIRCRESAHA.122.322227

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© 2023 The Authors.

Circulation Research is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution Non-Commercial-NoDerivs License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited, the use is noncommercial, and no modifications or adaptations are made.

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Figure 7. — ZBP1 (Z-DNA binding protein 1) knockout (KO) exacerbates cardiac dysfunction and remodeling after myocardial infarction (MI). A, The representative echocardiographic images of ZBP1 KO and wild type (WT) mice hearts 28 days after left anterior descending artery (LAD) ligation (n=38) or sham operation (n=5). Long 2-way arrows and short 2-way arrows indicate left ventricular end-diastolic diameter (LVDd) and left ventricular end-systolic diameter (LVDs), respectively. B, Heart weight to tibial length (TL) ratio and left ventricle (LV) weight to TL ratio (n of sham, 8; n of LAD ligation, 41) in each group. C, Masson-trichrome-stained heart section in each group. Interstitial fibrosis was assessed by collagen volume in each group (n=5). Cardiomyocyte hypertrophy was assessed by cross-sectional area in each group (n=5). Error bars denote standard errors. Data were analyzed using the Wilcoxon rank sum test (A, LVDd; B and C, collagen volume; adjust, 3), and 2-way ANOVA followed by Tukey multiple comparisons test (A, except for LVDd and C, cross sectional area).