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. 2023 Apr 21;24(8):7650. doi: 10.3390/ijms24087650

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic view of platelet transcriptome/proteome modulation upon activation. This diagram illustrates the complex interplay between platelets’ transcriptome and proteome via miRNAs and mRNA alternative splicing. It is also reported that noncoding RNAs might affect the transcriptome (see text for details). Finally, post-translational modifications may occur once platelet proteins are synthesized. MiRNA: microRNA; lncRNA: long-noncoding RNA; snoRNA: small-nucleolar RNAs; circRNA: circular RNA; piRNA: piwi RNA.