Table 1.

RNA-related mechanisms involved in platelet function.

RNA-Related Activity	Nucleotides	Function	Relevance
miRNA	~22	Downregulation of protein synthesis	Most studied platelet ncRNAs
Alternatively spliced mRNA		Different exons combinations from the same gene, leading to different, but related, mRNA transcripts	An important mechanism in anucleate cells with prespecified transcriptome to modulate protein synthesis
lncRNA	>200	Role in platelet reactivity	Highly involved in megakaryocytes development and platelet production
snoRNA	60–200	Possible role in platelet activation	The primary function is to guide nucleotide modifications in rRNA
Y-RNA	100 ± 20	Possible role in platelet function	Involvement DNA replication, RNA stability, and cellular stress responses
piRNA	26–32	Possible synergism with miRNAs to promote megakaryocyte differentiation	A silencing complex able to suppress transposable elements
circRNA	single-stranded RNA that forms a covalently closed continuous loop	Highly abundant in human platelets with a not-well-defined function	Putative role in mRNA stability