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. 2023 Apr 17;16(4):606. doi: 10.3390/ph16040606

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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A 73-year-old patient with a diagnosis of urothelial carcinoma. (Upper row): Baseline FDG-PET/CT shows a diffuse pararectal et mesorectal infiltration, with a faint FDG uptake, surgically confirmed as peritoneal metastasis. (Lower row): Same patient seen after 6 cycles of neoadjuvant chemotherapy. FDG-PET/CT shows a complete regression of the posterior pelvis infiltration. The case illustrates the infiltrative nature of low tumor cell density in rare urothelial carcinoma cases, requiring special attention when FDG-PET/CT is used as a systemic staging modality.