Table 1.
LBNP components.
| Abbreviation | Definition |
|---|---|
| Cationic Lipids | |
| C12-200 | 1,1′-((2-(4-(2-((2-(bis(2-hydroxydodecyl)amino)ethyl)(2-hydroxydodecyl)amino)ethyl)piperazin-1-yl)ethyl)azanediyl)bis(dodecan-2-ol) (pKa 7) |
| CL | Cationic Lipid |
| DOTAP | 1,2-dioleoyl-3-trimethylammonium-propane (pKa 7.8) |
| Ionizable Cationic Lipids | |
| CL4 lipids | Ionizable cationic lipids, pKa ~6.3 |
| CL7 lipids | Ionizable cationic lipids, pKa ~5.9 |
| CL15 lipids | Ionizable cationic lipids, pKa ~7.3 |
| DLin-MC3-DMA | Dilinoleylmethyl-4-dimethylaminobutyrate (pKa 6.4) |
| DODAP | 1,2-dioleoyl-3-dimethylammonium-propane (pKa < 7) |
| YSK05 | 1-methyl-4,4-bis(((9Z,12Z)-octadeca-9,12-dien-1-yl)oxy)piperidine (pKa 6.5) |
| Anionic Lipids | |
| DOPA | 1,2-dioleoyl-sn-glycero-3-phosphate |
| EPG | Egg phosphatidylglycerol |
| Neutral Lipids | |
| DMPC | Dimyristoylphosphatidylcholine |
| DOPC | 1,2-dioleoyl-sn-glycero-3-phosphocholine |
| DOPE | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine |
| DPPC | 1,2-dipalmitoyl-sn-glycero-3-phosphocholine |
| DSPC | 1,2-Distearoyl-sn-glycero-3-phosphocholine |
| HSPC | Hydrogenated soybean phoshatidylcholine |
| PC | Phosphatidylcholine |
| Stabilizing Agents and Lipids | |
| Chol | Cholesterol |
| DMG-mPEG 2000 | 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000 |
| DSPE-PEG 2000 Amine | 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[amino(polyethylene glycol)-2000] |
| ESM | Egg sphingomyelin |
| PEG | Polyethylene glycol |