Figure 4.

Identification of eccDNA from long-read sequencing of eccDNA enrichment samples derived from human and mouse cells. A) Hexagonal bin plots showing no correlation between the length of the identified eccDNA with their coverage depth. B) Bar plots showing the fraction of the identified eccDNA containing variants (SNVs and/or INDELs) based on a quality cut-off of 20. C) Bar plots showing the distribution of deletions, insertions, and SNVs of the identified eccDNA. D) Circos plots visualizing the architecture of three selected human eccDNA datasets. E) Circos plots visualizing the architecture of three selected mouse eccDNA datasets (see Figure 1.5 for lane annotation; data set information (bold), eccDNA name (italics), coverage depth (underline).