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. 2022 Nov 16;23(6):bbac473. doi: 10.1093/bib/bbac473

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Illustration of secure kinship and IBD-Sharing probability estimation for 2-site collaboration. (A) Site-2 estimates individual specific allele frequencies and computes the normalized genotypes , and indicator matrices , and sends them to Site-1 after encrypting them with the public key. Site-1 also computes the normalized genotype matrix, and the indicator matrices. After receiving the encrypted genotype matrix from Site-2, Site-1 securely estimates the encrypted kinship () and zero-IBD sharing probability matrix () shown in step 4. Site-1 sends the encrypted matrices to Site-2, which decrypts the kinship statistics and shares them with Site-2. (B) The time requirements of the secure kinship estimation (y-axis in seconds) of the HAPMAP project’s 86 MEX samples with respect to increasing number of variants (x-axis). (C) Memory requirements of secure kinship estimation (y-axis in megabytes) with respect to increasing number of variants (x-axis).

Inline graphic — Illustration of secure kinship and IBD-Sharing probability estimation for 2-site collaboration. (A) Site-2 estimates individual specific allele frequencies and computes the normalized genotypes , and indicator matrices , and sends them to Site-1 after encrypting them with the public key. Site-1 also computes the normalized genotype matrix, and the indicator matrices. After receiving the encrypted genotype matrix from Site-2, Site-1 securely estimates the encrypted kinship () and zero-IBD sharing probability matrix () shown in step 4. Site-1 sends the encrypted matrices to Site-2, which decrypts the kinship statistics and shares them with Site-2. (B) The time requirements of the secure kinship estimation (y-axis in seconds) of the HAPMAP project’s 86 MEX samples with respect to increasing number of variants (x-axis). (C) Memory requirements of secure kinship estimation (y-axis in megabytes) with respect to increasing number of variants (x-axis).