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. 2023 Apr 1;13(4):510. doi: 10.3390/metabo13040510

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Higher pre-pregnancy BMI and higher age at delivery are associated with increased free carnitine (C0) and acetylcarnitine (C2) at birth, respectively, in both the A) discovery (n = 2285) and B) replication (n = 1207) cohorts. Multivariable linear regression was used to assess associations between higher BMI and C0 and higher age at delivery and C2. These analyses were adjusted for birth weight, gestational age, infant race, infant ethnicity, sex, cohort (discovery phase only), and all other maternal health characteristics. C0 and C2 were log-transformed. Point estimates were estimated for an 8.7 unit (interquartile range) increase in pre-pregnancy BMI and an 8-year increase in maternal age at delivery.