Table 2.
Bacteriophage therapy for P. aeruginosa.
| Treatment/Study | Mechanism of Action | Population | Purpose | Phase | Number of Patients | Reference/Year |
|---|---|---|---|---|---|---|
| MUCOPHAGES (10 Pseudomonas specific bacteriophages) (NCT01818206) |
Binding of bacteriophage to specific Pseudomonas targets to induce lysis | Cystic fibrosis sputa | Clinical study | -- | 59 | 2012, [225] |
| PhagoBurn (PP1131) 12 natural lytic Pseudomonas bacteriophages (NCT02116010) |
Binding of bacteriophage to specific Pseudomonas targets to induce lysis | Burn patients | Treat P. aeruginosa burn wound infection | I/II | -- | 2018, [224] |
| B-PAO1 (4 Pseudomonas-specific bacteriophages) (NCT03395743) |
Binding of bacteriophage to specific Pseudomonas targets to induce lysis | Cystic fibrosis patients | Prevent/treat P. aeruginosa infection | -- | -- | 2019, [226] |
| Bacteriophage cocktail spray (Phage cocktail-SPK) (NCT04323475) |
Binding of bacteriophage to specific Pseudomonas targets to induce lysis | Burn patients | Treatment of P. aeruginosa and infection of burn wounds | I | 12 | 2023, [227] |
| AP-PA02 (NCT04596319) |
Binding of bacteriophage to specific Pseudomonas targets to induce lysis | Chronic P. aeruginosa lung infections and CF | Treatment of chronic P. aeruginosa lung infections and CF | I/II | 29 | 2022, [228] |
| YPT-01 (NCT04684641) |
Binding of bacteriophage to specific Pseudomonas targets to induce lysis | Chronic P. aeruginosa lung infections and CF | Treatment of chronic P. aeruginosa lung infections and CF | I/II | 8 | 2023, [229] |