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. 2023 Apr 28;8:172. doi: 10.1038/s41392-023-01432-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Humoral Immune Response in mRNA-A-LNP and mRNA-B-LNP-Vaccinated Mice. Female BALB/c mice were immunized with 40 μg mRNA-A-LNP vaccine or 40 μg mRNA-B-LNP vaccine or were designated negative controls (n = 10). Two intramuscular immunizations were on day 0 and day 14, respectively. Serum was collected 10 and 24 days after the initial vaccination. a Schematic diagram of immunization, sample collection, and challenge schedule. b–e The MPXV-specific antigen A29L, A35R, M1R and B6R IgG antibody titer was determined by ELISA. f The NT₅₀ was determined by neutralizing antibody assay based on live VACV. The dashed line indicates the limit of detection of the assay. Data are shown as mean ± SEM. Significance was calculated using two-way ANOVA with multiple comparison tests (n.s., not significant; **p < 0.01)