Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr 28;8:172. doi: 10.1038/s41392-023-01432-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — The safety evaluation of MPXV quadrivalent mRNA vaccine in mice. a The body weight records of mice on the first eight days after each vaccination. b–f Heart, liver and kidney function were determined by blood biochemical parameters (n = 5). CK, CK-MB and LDH1 represent heart function (b), ALT, ALP and TP represent liver function (c, d), while UREA, CREA and UA represent kidney function (e, f). g The immune activation effect of the vaccine was expressed by analysis of cytokines in innate immunity (n = 5). h Representative histopathology (H&E) of different tissues, liver, heart, spleen, lung and kidney from naive mice or mRNA vaccine-immunized mice. The H&E stained sections shown in the data are representative results from three test mice 48 h post-inoculation. Scale bar = 100 μm, 30×. Data are shown as mean ± SEM. Significance was calculated using two-way ANOVA with multiple comparison tests (n.s., not significant; *p < 0.05, **p < 0.01)