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. 2023 Apr 28;14:2462. doi: 10.1038/s41467-023-37990-z

Fig. 2. Micron-sized particles outperform nano-sized particles in modulating platelet and leukocyte adhesion to an inflamed endothelium in human blood.

Fig. 2

Change in platelet and leukocyte adhesion to a damaged, inflamed endothelium with the addition of untargeted (a) 4.5 µm, (b) 500 nm, or (c) 200 nm IgG-conjugated polystyrene particles. N = 5 independent donors were utilized for each particle treatment with 2 replicates per donor utilized for each (non-treatment) control. Statistical analyses were performed using two-way ANOVA with Sidak’s multiple comparison tests. (*) indicates p < 0.05, (**) indicates p < 0.01, (***) indicates p < 0.001, and (****) indicates p < 0.0001 in comparison to no particle controls. Lack of symbols indicates no statistical significance. Circles represent individual data points, horizontal bar represents the average of individual data points, and error bars represent standard error. Source data and specific p-values are provided as a Source Data file.