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. 2023 Apr 28;14:2462. doi: 10.1038/s41467-023-37990-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Platelet adhesion scaled by the surface area of the blood vessel. b The percentage of total platelets on the mesentery associated with a bound neutrophil (PMN). c The average number of platelets adherent to each adherent neutrophil in the mesentery. d Salicylic acid present in mouse plasma at the time of euthanasia as measured by liquid chromatography with tandem mass spectrometry (LC-MS/MS). e Schematic detailing the mechanism of reducing platelet-leukocyte aggregates to an inflamed mouse mesentery in vivo due to micron-sized, Poly-A polymeric particles. Experimental groups consist of N = 5 mice per group with 2–4 independent vessels imaged per mouse and N ≥ 3 for salicylic acid measurements. Statistical analyses were performed using a one-way ANOVA with Tukey’s multiple comparisons (a–c) or a two-tailed unpaired Student’s t test (d). (*) indicates p < 0.05 and (**) indicates p < 0.01 in comparison to LPS-only controls. (****) indicates p < 0.0001 compared to mice receiving Poly-A particles (d). Lack of symbols indicates no statistical significance. Circles represent individual data points, bar graph represents the average of individual data points, and error bars represent standard error. ‘VC’ = vehicle control (10% DMSO in PBS) for the free aspirin assay. ‘LPS’ = lipopolysaccharide. Source data and specific p-values are provided as a Source Data file.