Figure 1.

Peptide histochemistry and Congo red analysis of tissue sections demonstrate the pan-amyloid reactivity of p5+14. The brown-colored stain of biotinyl-p5+14 can be seen in (A) patient-derived renal tissues, magnification 10×; (B) patient-derived cardiac tissues, magnification 20×; and (C) animal-derived tissues, magnification 10×. The peptide colocalized to Congophilic regions within tissue, as demonstrated with green–gold birefringence in consecutive tissue sections. (D) Normal heart (left) and kidney (right) tissues were negative with biotinyl-p5+14, magnification 10×.