Table 2.
Constituent lipid information on approved RNA LNP products.
| Product Name | Sponsor | Ionizable Lipid | Structural Lipid | pKa of Ionizable Lipid | Ref. |
|---|---|---|---|---|---|
| Onpattro | Alnylam Pharmaceuticals, Inc. |
 DLin-MC3-DMA |
Cholesterol, DSPC, PEG2000-C-DMG | 6.35 | [5] |
| Comirnaty | Pfizer Inc. |
 ALC-0315 |
Cholesterol, DSPC, ALC-0159 | 6.09 | [5] |
| Spikevax | Moderna |
 SM-102/Lipid-H |
Cholesterol, DSPC, PEG2000-DMG | 6.68 | [6] |
Abbreviations: DLin-MC3-DMA: (6Z,9Z,28Z,31Z)-heptatriacont-6,9,28,31-tetraene-19-yl 4-(dimethylamino)butanoate; DSPC: 1,2-distearoyl-sn-glycero-3-phosphocholine; PEG2000-C-DMG: 1,2-dimyristoyl-rac-glycero-3-carbonylaminoethyl-ω-methoxypolyethylene glycol-2000; ALC-0315: (4-hydroxybutyl) azanediyl) bis (hexane-6,1-diyl) bis (2-hexyldecanoate); ALC-0159: 2-(polyethylene glycol 2000)-N,N-ditetradecylacetamide; PEG2000-DMG: 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000.