Figure 1.
Expression patterns of Wnts and chondrocyte marker genes in primary articular chondrocyte cultures in vitro. (A) Expression of Wnts in cultured articular chondrocytes isolated from 1-week-old C57BL/6J mice (fold-change data vs. Wnt5b is expressed in the log scale). (B) Quantitation of expression of genes 24 (n = 5) and 72 h post rhWNT16 treatment (n = 5) in chondrocytes derived from epiphyses of 1-week-old C57BL/6J mice. (C) Quantitation of expression of Wnt ligands 24 and 72 h post rhWNT16 treatment in chondrocytes isolated from the epiphyses of 1-week-old C57BL/6J mice (n = 3). Values are the mean ± SEM. A p < 0.05 and B p = 0.06 vs. vehicle, * p = 0.08 vs. vehicle. The x-axis represents the genes studied and y-axis reflects fold-change in expression.