Algorithm 1: Pseudo-code to determine sample’s steady-state region

For each sample n: Sort the drug released value based on time (t) in ascending order. Assign the first two initial data points, starting from time zero (t = 0), into set A which corresponds to region A. Assign the remaining data points to set B which corresponds to region B. While the p-value of region B > significance level (0.05): ○ Remove the first data point from set B and assign to set A. ○ Create a linear regression model using the data in set A (model A). ○ Create a linear regression model using the data in set B (model B). ○ If the p-value of model B is above the significance level (0.05), move to the next iteration. ○ If the p-value of model B is below the significance level (0.05), terminate the while loop. ○ If all data points have been assigned to set A, terminate the while loop because there is no more data in region B. Move to the next sample. End