Skip to main content
. 2023 Mar 31;16(4):522. doi: 10.3390/ph16040522

Figure 3.

Figure 3

The inhibitory effect of statins on the MSU-induced inflammatory response is attenuated in PPAR-γ deficient cells. (A) NLRP3, caspase-1, and IL-1β mRNA expression by addition of statins in THP-1 cells transfected with and without PPAR-γ siRNA under stimulation with MSU crystals (0.3 mg/mL). (B) PPAR-γ, NLRP3, caspase-1, and IL-1β protein expression by addition of statins in THP-1 cells transfected with and without PPAR-γ siRNA under stimulation with MSU crystals (0.3 mg/mL). *: p < 0.05, compared to cells transfected with NC siRNA using Kruskal–Wallis test followed by Dunn’s multiple comparison test. Values presented as mean ± SEM of three independent experiments. Images are representative of three independent experiments. Abbreviations: PPAR-γ, peroxisome proliferator-activated receptor-γ; MSU, monosodium urate; IL-1β, interleukin-1β; ATO, atorvastatin; SIM, simvastatin; and MEV, mevastatin.