Table 5.
Urinary excretion of tryptophan (TRP) and its metabolites: 5-hydroxyindoleacetic acid (5-HIAA), kynurenine (KYN), kynurenic acid (KYNA), and quinolinic acid (QA) in patients with diarrhea-predominant irritable bowel syndrome without (IIA) and with (IIB) reduction of TRP intake; before (a) and after (b) nutritional intervention; all results expressed in units—mg/gCr; average ± SD.
| TRP and Its Metabolites | Group IIA | Group IIB | ||||
|---|---|---|---|---|---|---|
| A | B | p | a | b | p | |
| TRP | 11.4 ± 2.31 | 10.9 ± 1.93 | >0.05 | 12.5 ± 2.29 | 10.6 ± 2.06 | >0.05 |
| 5-HIAA | 6.31 ± 0.96 | 5.82 ± 1.02 | >0.05 | 6.81 ± 0.91 | 3.21 ± 0.88 | <0.001 |
| KYN | 0.87 ± 0.21 | 0.82 ± 0.19 | >0.05 | 0.83 ± 0.21 | 0.80 ± 0.21 | >0.05 |
| KYNA | 2.41 ± 0.66 | 2.74 ± 0.71 | >0.05 | 2.17 ± 0.52 | 4.26 ± 0.62 | <0.001 |
| QA | 7.18 ± 1.22 | 6.92 ± 0.98 | >0.05 | 7.15 ± 0.87 | 3.90 ± 0.94 | <0.001 |