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. 2023 Mar 30;15(4):887. doi: 10.3390/v15040887

Figure 2.

Figure 2

General outline of the mouse mastitis model and experimental designs. Four experimental designs were used in this study. In experiment 1, various doses of StaphLyse™ were given intramammary (IMAM). In experiment 2, StaphLyse™ was given either IMAM 4 h after S. aureus infection, IMAM 8 h after infection, or IMAM 4 h after infection followed by intra veinous (IV) 4 h later (at 8 h). In experiment 3, StaphLyse™ was injected via the IMAM route at 8 and/or at 16 h after S. aureus infection. In experiment 4, the model was used to evaluate the efficacy of prophylactic treatment. StaphLyse™ was injected via the IMAM route either 4 h prior to (−4) or 4 h after (+4) S. aureus infection. The results of these experiments are shown in Figures 6–9.