Figure 8.

Efficacy of single and repeated doses of StaphLyse™ administered IMAM in the S. aureus mouse mastitis model. S. aureus ATCC 29740 was inoculated IMAM, at a concentration of 100 CFU in a volume of 100 µL in the 2 fourth glands, in lactating CD-1 mice separated from pups 1 h prior to infection. StaphLyse™ (10⁸ PFU in 100 µL) was administered IMAM 8 h and/or 16 h after the infection. Glands were harvested (2 per mouse) 24 h after infection. Each dot on the graph represents the bacterial load for each gland. Amoxicillin was used as a comparator and was administered IMAM at a concentration of 75 µg per gland. The horizontal bars within the boxes indicate the median value for each group. The whiskers show the minimum and maximum values. Statistical significance was determined using the Kruskal–Wallis comparison test followed by Dunn’s multiple-comparison tests (ns: not significant, * p = 0.02, *** p ˂ 0.001, **** p ˂ 0.0001).