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Sliding window analysis of alphavirus CpG content. The ratio of observed CpG dinucleotide frequency to expected frequency based on mononucleotide content (observed/expected) was calculated across alphavirus genomes using a window size of 500-bp and a step size of 250-bp. The genomes were aligned from the start of their 5′ untranslated regions. Windows with CpG contents that correlate with alphavirus replication sensitivity to ZAP are annotated (windows 1–3).
